La Merie
Ulrich Martin

Ulrich Martin

STUTTGART, Germany I August 10, 2016 I Immunotherapy of B-cell malignancies with specifically targeted autologous T-cells most probably will see the first adoptive cell therapy products approved in the year 2017. Novartis, Kite Pharma and Juno Therapeutics are in a head-to-head race to be first on the market with anti-CD19 chimeric antigen receptor (CAR) T-cells. However, the success story with CD19 CAR T-cells is not as easily repeated with CAR T-cells directed against other targets in hematologic malignancies and - even more - in solid tumors. Limitations by lack of target specificity resulting in on-target, off-tumor toxicity, is one of the major hurdles associated with insufficient activity of current CAR constructs.

As a consequence, the limitations are adressed by a multitude of measures. Gene editing capabilities appears as a key technology not only to generate allogeneic CAR T-cells from donor cells or renewable, pluripotent stem cells, but also to bring CAR design and engineering to a new level of multiplex editing. Knock-out of auto-antigens or immune checkpoints, but also incorporation of on- and off switches for controlling of T-cell activity and enhance potency are some of the features enableb by genome editing of T-cells.

In a new report released by La Merie Publishing, the competitive landscape of CAR T-Cell stakeholders, technologies, pipelines, financing and deals is described and analyzed.

This report „TCR & CAR Engineered T-Cell and NK Cell Therapeutics 2016: Convergence of technologies opens business opportunities beyond CD19 CARTs“ describes and analyzes the status of the adoptive cell therapy industry as of August 2016. The report covers autologous and allogeneic engineered chimeric antigen receptor (CAR) and T-cell receptor (TCR) T-cell therapy candidates as well as natural killer (NK) cell and CAR engineered NK cells in research and development by biopharmaceutical companies. Cytotoxic lymphocytes (CTLs), donor lymphocyte infusions (TILs) and tumor infiltrating lymphocytes (TILs) complement the spectrum of the report.

About La Merie

La Merie Publishing is a Business Intelligence enterprise fully dedicated to provide high quality R&D information to the biopharmaceutical industry. La Merie offers individual consultancy services and publishes reports and periodicals. For more information visit www.lamerie.com and www.PipelineReview.com, the Biologics News Center and Online Store of La Merie Publishing.

SOURCE: La Merie Publishing

STUTTGART, Germany I August 10, 2016 I Immunotherapy of B-cell malignancies with specifically targeted autologous T-cells most probably will see the first adoptive cell therapy products approved in the year 2017. Novartis, Kite Pharma and Juno Therapeutics are in a head-to-head race to be first on the market with anti-CD19 chimeric antigen receptor (CAR) T-cells. However, the success story with CD19 CAR T-cells is not as easily repeated with CAR T-cells directed against other targets in hematologic malignancies and - even more - in solid tumors. Limitations by lack of target specificity resulting in on-target, off-tumor toxicity, is one of the major hurdles associated with insufficient activity of current CAR constructs.

As a consequence, the limitations are adressed by a multitude of measures. Gene editing capabilities appears as a key technology not only to generate allogeneic CAR T-cells from donor cells or renewable, pluripotent stem cells, but also to bring CAR design and engineering to a new level of multiplex editing. Knock-out of auto-antigens or immune checkpoints, but also incorporation of on- and off switches for controlling of T-cell activity and enhance potency are some of the features enableb by genome editing of T-cells.

In a new report released by La Merie Publishing, the competitive landscape of CAR T-Cell stakeholders, technologies, pipelines, financing and deals is described and analyzed.

This report „TCR & CAR Engineered T-Cell and NK Cell Therapeutics 2016: Convergence of technologies opens business opportunities beyond CD19 CARTs“ describes and analyzes the status of the adoptive cell therapy industry as of August 2016. The report covers autologous and allogeneic engineered chimeric antigen receptor (CAR) and T-cell receptor (TCR) T-cell therapy candidates as well as natural killer (NK) cell and CAR engineered NK cells in research and development by biopharmaceutical companies. Cytotoxic lymphocytes (CTLs), donor lymphocyte infusions (TILs) and tumor infiltrating lymphocytes (TILs) complement the spectrum of the report.

About La Merie

La Merie Publishing is a Business Intelligence enterprise fully dedicated to provide high quality R&D information to the biopharmaceutical industry. La Merie offers individual consultancy services and publishes reports and periodicals. For more information visit www.lamerie.com and www.PipelineReview.com, the Biologics News Center and Online Store of La Merie Publishing.

SOURCE: La Merie Publishing

STUTTGART, Germany I May 13, 2016 I Immunotherapy of cancer with direct or indirect use of T-cells is one of the most exciting fields in cancer research. Direct T-cell therapy implies the ex vivo engineering of autologous or allogeneic T-cells for tumor targeting by chimeric antigen receptors (CAR) or T-cell receptors (TCR). Despite stunning clinical results with CD19-targeted CAR T-cells, many major pharmaceutical companies have not embarked on adoptive cell therapy, probably because cell products are a world completely different from that of small molecules or recombinant proteins and antibodies.

Tremendous progress in bispecific antibody technologies during the last decade and the clinical success of a first generation bispecific T-cell engager (BiTE) antibody molecule directed against CD19 lead to an explosion of T-cell redirecting bispecific antibodies in clinical development. Within 18 months, the number of clinical stage T-cell or natural killer (NK) cells redirecting bispecific antibodies has increased from 4 to 21 and further 16 molecules could enter clinical development within the next 12 months. Data from these clinical studies in the next years will give valuable feedback for the further design of T-cell redirecting bispecific constructs.

In a new report released by La Merie Publishing, the competitive T-cell redirecting bispecific antibody stakeholders, technologies, pipelines and deals is described and analyzed.

This report „T-Cell Redirecting Bispecific Antibodies 2016: A competitive landscape analysis of stakeholders, technologies, pipelines and deals“ provides up-to-date information about and analysis of 34 corporate players, 22 key technologies, 47 T-cell and NK-cell redirecting bispecific antibody profiles, business deals and private and public financing rounds.

The report analyzes the pipeline of T-cell and NK-cell redirecting bispecific antibody molecules regarding preferred targets, molecular constructs, dosing schedules, clinical experience, combination study plans, competition with other treatment modalities and the next wave of T-cell and NK-cell redirecting antibodies.

Preferences in bispecific antibody technologies are evaluated regarding drug candidate output, partnering, technological features and impact on clinical administration regimens.

The report highlights the commercial value of T-cell redirecting bispecific antibody immunotherautics in terms of drug prices, sales, company acquisition prices, economic terms of partnering deals, and private or public financing rounds.

About La Merie

La Merie Publishing is a Business Intelligence enterprise fully dedicated to provide high quality R&D information to the biopharmaceutical industry. La Merie offers individual consultancy services and publishes reports and periodicals. For more information visit www.lamerie.com and www.PipelineReview.com, the Biologics News Center and Online Store of La Merie Publishing.

SOURCE: La Merie Publishing

STUTTGART, Germany I May 13, 2016 I Immunotherapy of cancer with direct or indirect use of T-cells is one of the most exciting fields in cancer research. Direct T-cell therapy implies the ex vivo engineering of autologous or allogeneic T-cells for tumor targeting by chimeric antigen receptors (CAR) or T-cell receptors (TCR). Despite stunning clinical results with CD19-targeted CAR T-cells, many major pharmaceutical companies have not embarked on adoptive cell therapy, probably because cell products are a world completely different from that of small molecules or recombinant proteins and antibodies.

Tremendous progress in bispecific antibody technologies during the last decade and the clinical success of a first generation bispecific T-cell engager (BiTE) antibody molecule directed against CD19 lead to an explosion of T-cell redirecting bispecific antibodies in clinical development. Within 18 months, the number of clinical stage T-cell or natural killer (NK) cells redirecting bispecific antibodies has increased from 4 to 21 and further 16 molecules could enter clinical development within the next 12 months. Data from these clinical studies in the next years will give valuable feedback for the further design of T-cell redirecting bispecific constructs.

In a new report released by La Merie Publishing, the competitive T-cell redirecting bispecific antibody stakeholders, technologies, pipelines and deals is described and analyzed.

This report „T-Cell Redirecting Bispecific Antibodies 2016: A competitive landscape analysis of stakeholders, technologies, pipelines and deals“ provides up-to-date information about and analysis of 34 corporate players, 22 key technologies, 47 T-cell and NK-cell redirecting bispecific antibody profiles, business deals and private and public financing rounds.

The report analyzes the pipeline of T-cell and NK-cell redirecting bispecific antibody molecules regarding preferred targets, molecular constructs, dosing schedules, clinical experience, combination study plans, competition with other treatment modalities and the next wave of T-cell and NK-cell redirecting antibodies.

Preferences in bispecific antibody technologies are evaluated regarding drug candidate output, partnering, technological features and impact on clinical administration regimens.

The report highlights the commercial value of T-cell redirecting bispecific antibody immunotherautics in terms of drug prices, sales, company acquisition prices, economic terms of partnering deals, and private or public financing rounds.

About La Merie

La Merie Publishing is a Business Intelligence enterprise fully dedicated to provide high quality R&D information to the biopharmaceutical industry. La Merie offers individual consultancy services and publishes reports and periodicals. For more information visit www.lamerie.com and www.PipelineReview.com, the Biologics News Center and Online Store of La Merie Publishing.

SOURCE: La Merie Publishing

STUTTGART, Germany I March 13, 2016 I 2015 was another year of record sales of recombinant therapeutic proteins and antibodies despite the beginning commercialization of biosimilar antibodies and proteins. Global sales of originator antibodies and proteins reached USD 154 bln, a growth of 9.2% compared with the previous year. While sales of anti-TNF antibodies slowed down, the strong growth was mainly due to antibodies (+11.3%) driven by sales of cancer antibodies and other anti-inflammatory antibodies. The commercially most successful class of protein products were insulin and insulin analogs with growth of 11.9% from 2014 to 2015. On the contrary, the successful lauch and market uptake of oral antivirals to treat hepatitis C cut interferon alpha sales by 50%

A total of 39 biologic therapeutics reached blockbuster status with 2015 sales exceeding US$ 1 bln: 21 antibodies and 18 proteins. Nine biologics reached global sales in 2015 of more than US$ 5 bln. Four biologics were new in the blockbuster biologics list and one dropped out. Six biopharmaceutical companies posted combined biologics sales of more than US$ 10 bln in the year 2015.

Quite a number of new therapeutic antibodies and proteins were launched in the year 2015 and will contribute to the further growth of biologics sales, but also to compensate for expected losses of blockbuster biologics by biosimilar antibodies and proteins or by new competitors.

The report „Blockbuster Biologics 2015: Sales of Recombinant Therapeutic Antibodies & Proteins“ can be acquired at La Merie Publishing’s News Center and Online Store www.PipelineReview.com: http://pipelinereview.com/index.php/store-online/blockbuster-biologics-2015-sales-of-recombinant-therapeutic-antibodies-proteins-detail

The report provides a compilation of the sales data of recombinant therapeutic proteins and antibodies in the calendar year 2015. Sales data were obtained from company publications and refer to branded products originating from companies based in regulated markets. All sales data were converted from their original, published currency into US$. Sales figures represent the sum of revenues in all territories where the products were marketed. Growth rates usually are listed as reported (not based on constant exchange rates).

Sales data are presented for each product within the respective class of biologics. The data were analyzed to establish a ranking list of blockbuster biologics with 2015 sales higher than US$ 1 bln. Another ranking list was prepared for companies according to biologics sales in 2015 and the percentage of antibody sales vs protein sales.

About La Merie

La Merie Publishing is a Business Intelligence enterprise fully dedicated to provide high quality R&D information to the biopharmaceutical industry. La Merie offers individual consultancy services and publishes reports and periodicals. For more information visit www.lamerie.com and www.PipelineReview.com, the Biologics News Center and Online Store of La Merie Publishing.

SOURCE: La Merie Publishing

STUTTGART, Germany I March 14, 2016 I 2015 was another year of record sales of recombinant therapeutic proteins and antibodies despite the beginning commercialization of biosimilar antibodies and proteins. Global sales of originator antibodies and proteins reached USD 154 bln, a growth of 9.2% compared with the previous year. While sales of anti-TNF antibodies slowed down, the strong growth was mainly due to antibodies (+11.3%) driven by sales of cancer antibodies and other anti-inflammatory antibodies. The commercially most successful class of protein products were insulin and insulin analogs with growth of 11.9% from 2014 to 2015. On the contrary, the successful lauch and market uptake of oral antivirals to treat hepatitis C cut interferon alpha sales by 50%

A total of 39 biologic therapeutics reached blockbuster status with 2015 sales exceeding US$ 1 bln: 21 antibodies and 18 proteins. Nine biologics reached global sales in 2015 of more than US$ 5 bln. Four biologics were new in the blockbuster biologics list and one dropped out. Six biopharmaceutical companies posted combined biologics sales of more than US$ 10 bln in the year 2015.

Quite a number of new therapeutic antibodies and proteins were launched in the year 2015 and will contribute to the further growth of biologics sales, but also to compensate for expected losses of blockbuster biologics by biosimilar antibodies and proteins or by new competitors.

The report „Blockbuster Biologics 2015: Sales of Recombinant Therapeutic Antibodies & Proteins“ can be acquired at La Merie Publishing’s News Center and Online Store www.PipelineReview.com: http://pipelinereview.com/index.php/store-online/blockbuster-biologics-2015-sales-of-recombinant-therapeutic-antibodies-proteins-detail

The report provides a compilation of the sales data of recombinant therapeutic proteins and antibodies in the calendar year 2015. Sales data were obtained from company publications and refer to branded products originating from companies based in regulated markets. All sales data were converted from their original, published currency into US$. Sales figures represent the sum of revenues in all territories where the products were marketed. Growth rates usually are listed as reported (not based on constant exchange rates).

Sales data are presented for each product within the respective class of biologics. The data were analyzed to establish a ranking list of blockbuster biologics with 2015 sales higher than US$ 1 bln. Another ranking list was prepared for companies according to biologics sales in 2015 and the percentage of antibody sales vs protein sales.

About La Merie

La Merie Publishing is a Business Intelligence enterprise fully dedicated to provide high quality R&D information to the biopharmaceutical industry. La Merie offers individual consultancy services and publishes reports and periodicals. For more information visit www.lamerie.com and www.PipelineReview.com, the Biologics News Center and Online Store of La Merie Publishing.

SOURCE: La Merie Publishing

STUTTGART, Germany I February 4, 2016 I Targeting the proinflammatory cytokine interleukin-17 (IL-17) produced by T helper cells has become a clinically validated strategy of successfully treating psoriasis, psoriatic arthritis and ankylosing spondylitis. The first approved and marketed antibody secukinumab from Novartis also shows great commercial promise as evidenced by sales of US$ 261 mln in the first year of market launch. The success is due to superior efficacy of anti-IL17 over established psoriasis antibodies targeting TNFα and interleukin-12/23 with a multi-billion dollar market only for psoriasis. However, neutralizing IL-17 with antibodies has proved ineffective and possibly deleterious in patients with inflammatory bowel disease. Given that T helper 17 (TH17) cells express IL-17 together with many other proinflammatory cytokines (IL-17F, IL-22, IL-26, and granulocyte-macrophage colony-stimulating factor), targeting the Th17 cell lineage may be superior to blocking a single effector cytokine.

Th17 cells specifically express the DNA-binding transcription factor retinoic-acid-receptor-related orphan receptor gamma T (RORγT). The activity of RORγT is required for the proliferation and functionality of immune Th17 cells.. Active RORgammaT is a prerequisite for the differentiation of T cells into Th17 cells. Small-molecule inhibition of RORγT has therefore emerged as a novel strategy for the treatment of autoimmune diseases while stimulation of RORγT by agonists holds promise in immune-oncology. Orally bioavailable RORgamma agonists have demonstrated single agent therapeutic activity in multiple in vivo animal models of cancer. Ex vivo treatment with RORgamma agonist compounds has been shown to enhance the therapeutic benefit of adoptive T-cell therapy by improving both immune cell persistence and activation.

In a new report released by La Merie Publishing, the landscape of drug discovery and development of novel small molecule antagonists (inverse agonists) and agonists of RORγ is described and analyzed. Nuclear receptors are „difficult-to-drug“ targets, and, thus, represent a high entry barrier, which requires specific expertise in structure-based drug discovery.

The report entitled “RORgamma Modulators 2016: A comparative analysis of the landscape of RORgamma antagonists and agonists“ outlines the scientific rationale for discovering antagonists of RORgamma for treatment of autoimmune and inflammatory diseases, but also of agonists of RORgamma for treatment of cancer. Clinical as well as non-clinical data for validation of RORgamma as target are provided and lead and up-side indications for development including the key product profile are discussed. Potential safety concers for novel RORgamma modulators were identified. Drug discovery approaches of more than 30 technology and pharmaceutical companies are shown regarding strategies in partnering as well as in applied technologies.

Based on the experience in the past, estimates of the required time from start of a discovery program of RORgamma modulators until entry into human studies are calculated. The competitive landscape of RORgamma modulator development and discovery projects is analyzed and the profiles of companies are presented, separately for unpartnered technology or pharmaceutical companies and for partnerships between technology and pharmaceutical companies.

About La Merie

La Merie Publishing is a Business Intelligence enterprise fully dedicated to provide high quality R&D information to the biopharmaceutical industry. La Merie offers individual consultancy services and publishes reports and periodicals. For more information visit www.lamerie.com and www.PipelineReview.com, the Biologics News Center and Online Store of La Merie Publishing.

SOURCE: La Merie Publishing

STUTTGART, Germany I February 4, 2016 I Targeting the proinflammatory cytokine interleukin-17 (IL-17) produced by T helper cells has become a clinically validated strategy of successfully treating psoriasis, psoriatic arthritis and ankylosing spondylitis. The first approved and marketed antibody secukinumab from Novartis also shows great commercial promise as evidenced by sales of US$ 261 mln in the first year of market launch. The success is due to superior efficacy of anti-IL17 over established psoriasis antibodies targeting TNFα and interleukin-12/23 with a multi-billion dollar market only for psoriasis. However, neutralizing IL-17 with antibodies has proved ineffective and possibly deleterious in patients with inflammatory bowel disease. Given that T helper 17 (TH17) cells express IL-17 together with many other proinflammatory cytokines (IL-17F, IL-22, IL-26, and granulocyte-macrophage colony-stimulating factor), targeting the Th17 cell lineage may be superior to blocking a single effector cytokine.

Th17 cells specifically express the DNA-binding transcription factor retinoic-acid-receptor-related orphan receptor gamma T (RORγT). The activity of RORγT is required for the proliferation and functionality of immune Th17 cells.. Active RORgammaT is a prerequisite for the differentiation of T cells into Th17 cells. Small-molecule inhibition of RORγT has therefore emerged as a novel strategy for the treatment of autoimmune diseases while stimulation of RORγT by agonists holds promise in immune-oncology. Orally bioavailable RORgamma agonists have demonstrated single agent therapeutic activity in multiple in vivo animal models of cancer. Ex vivo treatment with RORgamma agonist compounds has been shown to enhance the therapeutic benefit of adoptive T-cell therapy by improving both immune cell persistence and activation.

In a new report released by La Merie Publishing, the landscape of drug discovery and development of novel small molecule antagonists (inverse agonists) and agonists of RORγ is described and analyzed. Nuclear receptors are „difficult-to-drug“ targets, and, thus, represent a high entry barrier, which requires specific expertise in structure-based drug discovery.

The report entitled “RORgamma Modulators 2016: A comparative analysis of the landscape of RORgamma antagonists and agonists“ outlines the scientific rationale for discovering antagonists of RORgamma for treatment of autoimmune and inflammatory diseases, but also of agonists of RORgamma for treatment of cancer. Clinical as well as non-clinical data for validation of RORgamma as target are provided and lead and up-side indications for development including the key product profile are discussed. Potential safety concers for novel RORgamma modulators were identified. Drug discovery approaches of more than 30 technology and pharmaceutical companies are shown regarding strategies in partnering as well as in applied technologies.

Based on the experience in the past, estimates of the required time from start of a discovery program of RORgamma modulators until entry into human studies are calculated. The competitive landscape of RORgamma modulator development and discovery projects is analyzed and the profiles of companies are presented, separately for unpartnered technology or pharmaceutical companies and for partnerships between technology and pharmaceutical companies.

About La Merie

La Merie Publishing is a Business Intelligence enterprise fully dedicated to provide high quality R&D information to the biopharmaceutical industry. La Merie offers individual consultancy services and publishes reports and periodicals. For more information visit www.lamerie.com and www.PipelineReview.com, the Biologics News Center and Online Store of La Merie Publishing.

SOURCE: La Merie Publishing

STUTTGART, Germany I December 2, 2015 I Only a few years ago, before the times of immuno-oncology and chimeric antigen receptor (CAR) T-Cell Therapeutics, antibody-drug conjugates (ADC) were the most exciting investment opportunity in oncology which nobody wanted to miss. Since then, the exaggerated expectations have waned because the early successes with Kadcyla and Adcetris could not be repeated as quickly as investors had hoped. Antibody-drug conjugates as a class, i.e. therapeutic antibodies empowered by intracellular delivery of cytotoxic drugs, so far did not prove as a money-making machine.

Some of the technological obstacles encountered on the way of maturation of antibody-drug conjugates were inappropriate patient selection, a narrow therapeutic window, drug resistance, and the heterogeneity of ADCs generated by conventional ADC technologies. Numerous technology as well as some major pharmaceutical companies have successfully worked on finding next generation ADC technology solutions to these problems.

In a brand-new report released by La Merie Publishing the field of antibody-drug conjugates was analyzed in depth by profiling more than 90 companies, more than 100 ADC drug candidates and more than 26 ADC technologies and components. The report entitled „Antibody-Drug Conjugates 2016: Perspectives & Opportunities - a Pipeline, Technology, Stakeholder & Business Analysis“ also described and analyzed business deals in the ADC field, e.g. collaboration and license agreements, mergers and acquisitions, financial transactions (divestments, public offerings, private equity and venture capital fund-raising).

The prospects for success of ADC drug candidates remain good and are based on a well-filled pipeline, increasing adoption of next generation ADC technologies, lessons learned from failures, a balanced mixture of stakeholders and a variety of options for funding of ADC developments. About 70 ADCs are in clinical and pre-IND stages of development and at least the same number of ADC programs are in preclinical R&D. However, targets are still a bottleneck with the attractive consequence that companies with successful target identification capabilities are highly rewarded by investors and business partners.

About La Merie

La Merie Publishing is a Business Intelligence enterprise fully dedicated to provide high quality R&D information to the biopharmaceutical industry. La Merie offers individual consultancy services and publishes reports and periodicals. For more information visit www.lamerie.com and www.PipelineReview.com, the Biologics News Center and Online Store of La Merie Publishing.

SOURCE: La Merie Publishing

STUTTGART, Germany I December 2, 2015 I Only a few years ago, before the times of immuno-oncology and chimeric antigen receptor (CAR) T-Cell Therapeutics, antibody-drug conjugates (ADC) were the most exciting investment opportunity in oncology which nobody wanted to miss. Since then, the exaggerated expectations have waned because the early successes with Kadcyla and Adcetris could not be repeated as quickly as investors had hoped. Antibody-drug conjugates as a class, i.e. therapeutic antibodies empowered by intracellular delivery of cytotoxic drugs, so far did not prove as a money-making machine.

Some of the technological obstacles encountered on the way of maturation of antibody-drug conjugates were inappropriate patient selection, a narrow therapeutic window, drug resistance, and the heterogeneity of ADCs generated by conventional ADC technologies. Numerous technology as well as some major pharmaceutical companies have successfully worked on finding next generation ADC technology solutions to these problems.

In a brand-new report released by La Merie Publishing the field of antibody-drug conjugates was analyzed in depth by profiling more than 90 companies, more than 100 ADC drug candidates and more than 26 ADC technologies and components. The report entitled „Antibody-Drug Conjugates 2016: Perspectives & Opportunities - a Pipeline, Technology, Stakeholder & Business Analysis“ also described and analyzed business deals in the ADC field, e.g. collaboration and license agreements, mergers and acquisitions, financial transactions (divestments, public offerings, private equity and venture capital fund-raising).

The prospects for success of ADC drug candidates remain good and are based on a well-filled pipeline, increasing adoption of next generation ADC technologies, lessons learned from failures, a balanced mixture of stakeholders and a variety of options for funding of ADC developments. About 70 ADCs are in clinical and pre-IND stages of development and at least the same number of ADC programs are in preclinical R&D. However, targets are still a bottleneck with the attractive consequence that companies with successful target identification capabilities are highly rewarded by investors and business partners.

About La Merie

La Merie Publishing is a Business Intelligence enterprise fully dedicated to provide high quality R&D information to the biopharmaceutical industry. La Merie offers individual consultancy services and publishes reports and periodicals. For more information visit www.lamerie.com and www.PipelineReview.com, the Biologics News Center and Online Store of La Merie Publishing.

SOURCE: La Merie Publishing

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