La Merie

Biologics Blog with Useful Links

During our daily work we come across a lot of information which might be useful for our customers and visitors from the biopharmaceutical industry. This blog will try to facilitate access to interesting data, reports and other information related to biologics, but not limited to. In addition, we will present our point of view and comment news in a fair, but succinct way. We hope you will enjoy our contributions and will appreciate any helpful comment and response from you.

STUTTGART, Germany I March 12, 2017 I Global sales of branded recombinant therapeutic antibodies and proteins in the calendar year 2017 reached an all time high of more than US$ 188 bln, as reported by La Merie Publishing. The increase by 11.9% compared with the previous year was driven by the double-digit growth of cancer antibodies and new anti-inflammatory antibodies, but also by the favorable currency exchange rate. 2017 was…
STUTTGART, Germany I January 25, 2018 I A tissue-based map of the human proteome suggests that about 75 % are intracellular or secreted targets not accessible for conventional monoclonal antibody and chimeric antigen receptor (CAR) T-cell therapy (Uhlen et al., Science, 2015). Thus, the large pool of intracellular protein targets, including overexpressed oncogenic proteins, mutated tumor suppressorsand gene products of translocation, remains untapped so far. Part of the intracellular antigen…
STUTTGART, Germany I June 23, 2017 I Overlooked for many years, RNA languished as the ugly stepchild of nucleic acid vaccine development and was thought to be a poor choice for a therapeutic agent given its short half-life in vivo and its immunogenicity. But two of the main problems of messenger RNA (mRNA) technologies, i.e. stability and manufacturing, sufficiently have been solved and optimized nanoparticlecarrer technologies enable targeted mRNA delivery…
STUTTGART, Germany I March 17, 2017 I Sales of branded originator biologics in 2016 continued to reach a record high of US$ 163 bln, a plus of 5.8% compared with the previous year. Growth drivers were therapeutic antibodies fortreatment of cancer and inflammatory diseases, especially the emerging immuno-oncology antibodies and novel anti-inflammatory antibodies different from anti-TNF. Interestingly, sales of all anti-inflammatory antibodies including the anti-TNF family were 63% higher than…
STUTTGART, Germany I January 25, 2017 I The acquisition of oncolytic virus company BioVex by Amgen in late 2011 for up to US$ 1 bln has been a game changer for the field of oncolytic viruses, now recognized as a promising new therapeutic approach for cancer treatment. The approval of Amgen‘s herpes simplex oncolytic virus Imlygic in late 2015 further strengthened this trend as evidenced by the fact that total…
STUTTGART, Germany I August 10, 2016 I Immunotherapy of B-cell malignancies with specifically targeted autologous T-cells most probably will see the first adoptive cell therapy products approved in the year 2017. Novartis, Kite Pharma and Juno Therapeutics are in a head-to-head race to be first on the market with anti-CD19 chimeric antigen receptor (CAR) T-cells. However, the success story with CD19 CAR T-cells is not as easily repeated with CAR…
STUTTGART, Germany I May 13, 2016 I Immunotherapy of cancer with direct or indirect use of T-cells is one of the most exciting fields in cancer research. Direct T-cell therapy implies the ex vivo engineering of autologous or allogeneic T-cells for tumor targeting by chimeric antigen receptors (CAR) or T-cell receptors (TCR). Despite stunning clinical results with CD19-targeted CAR T-cells, many major pharmaceutical companies have not embarked on adoptive cell…
STUTTGART, Germany I March 14, 2016 I 2015 was another year of record sales of recombinant therapeutic proteins and antibodies despite the beginning commercialization of biosimilar antibodies and proteins. Global sales of originator antibodies and proteins reached USD 154 bln, a growth of 9.2% compared with the previous year. While sales of anti-TNF antibodies slowed down, the strong growth was mainly due to antibodies (+11.3%) driven by sales of cancer…
STUTTGART, Germany I February 4, 2016 I Targeting the proinflammatory cytokine interleukin-17 (IL-17) produced by T helper cells has become a clinically validated strategy of successfully treating psoriasis, psoriatic arthritis and ankylosing spondylitis. The first approved and marketed antibody secukinumab from Novartis also shows great commercial promise as evidenced by sales of US$ 261 mln in the first year of market launch. The success is due to superior efficacy of…
STUTTGART, Germany I December 2, 2015 I Only a few years ago, before the times of immuno-oncology and chimeric antigen receptor (CAR) T-Cell Therapeutics, antibody-drug conjugates (ADC) were the most exciting investment opportunity in oncology which nobody wanted to miss. Since then, the exaggerated expectations have waned because the early successes with Kadcyla and Adcetris could not be repeated as quickly as investors had hoped. Antibody-drug conjugates as a class,…
Sunday, 03 November 2013 11:16

Rare Diseases R&D Pipeline

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By definition, rare disease are those disorders which affect less than 200,000 patients in the US. A new report lists the more than 450 compounds under development by US companies for treatment of rare diseases. The study was published by PhRMA, the Pharmaceutical Research and Manufacturers of America and can be downloaded at http://phrma.org/sites/default/files/pdf/Rare_Diseases_2013.pdf The range of rare diseases for which new drugs are being developing, is spanning from cancer…
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