Delta-like protein 3 (DLL3) Targeted Therapeutics – Target Pipeline List
Target: Delta-like canonical Notch ligand 3; delta-like protein 3; DLL3;; scr-like kinase Fyn3; SC-16
This Target Pipeline list provides an overview of antibody- and cell-based therapeutics targeting DLL3 in development for treatment of DLL3-overexpressing cancers.
Upregulated delta-like protein 3 (DLL3) functions as a Notch ligand and has been a target for cancer therapy. DLL3 is fundamental in the downstream cellular signaling for proliferation and apoptosis. DLL3 is an atypical member of the Notch receptor ligand family that is able to inhibit activation of the Notch receptors. DLL3 contains different functional domains (such as a Delta-Serrate-Lag2 [DSL] domain, epidermal growth factor [EGF] repeats, and a transmembrane domain). Aberrant DLL3 expression has been found in neuroendocrine cancers and high-grade serous ovarian cancer.
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