Tumor Stroma Targeting via FAP – Target Pipeline List 06/2019
Targets: Fibroblast activation protein; FAP
This Target Pipeline List provides an overview of FAP-targeted antibodies, fusion proteins and oncolytic viruses in development for treatment of stroma rich tumors.
Fibroblast activation protein (FAP) is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
Targeting of FAP is well suited for tumor stroma delivery of effector moieties such as cytokines, co-stimulatory agonists, redirected cytotoxic T-cells, and oncolytic viruses. Accordingly, antibody-based and multimeric fusion proteins as well as engineered oncolytic viruses with transgenes are in development for treatment of stroma rich tumorws.
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