GM-CSF Targeted Therapies
GM-CSF Targeted Therapies – Target Pipeline List 04/2019
Targets: GM-CSF; granulocyte macrophage-colony stimulating factor; GM-CSF receptor; GM-CSF-R
This Target Pipeline List provides an overview of therapeutic antibodies against GM-CSF or its receptor in development for treatment of inflammatory diseases.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a type of protein that plays a central role in a broad range of immune mediated diseases, including rheumatoid arthritis. It activates cells, including macrophages, leading to inflammation and joint damage. Neutralising the biological function of GM-CSF by blocking the interaction of GM-CSF with its cell surface receptor is a promising novel pharmacologic strategy for treatment of inflammatory diseases.
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