Landscape Analysis of Targeted Protein Degradation by Novel PROTACs and Molecular Glues
BARCELONA, Spain I May 14, 2020 I La Merie Publishing announced the release of its newest report about Targeted Protein Degradation. The report “Targeted Protein Degradation by Novel PROTACs and Molecular Glues 2020: a landscape analysis of companies, technologies, targets, investors and partners from an industry perspective” provides a landscape description and analysis of Targeted Protein Degradation (TPD) technologies and of discovery and development of TPD drug candidates from an industry perspective.
The online option allows the employee to complete some parts of the course that are not practical to complete in physical environment. The reasons for the scarcity of orlistat may have something to do with it not making it to market for costo viagra generico 100 mg in farmacia the promised launch period, but also a shortage that is not yet showing up in the marketplace. Clomid is a medication used to treat infertility, endometriosis, and heavy menstrual bleeding (menorrhagia).
It is an in-vitro treatment designed to mimic treatment with methadone. It may also cause a discharge of clear or red blood-stained liquid, called blood-shot clomifen kaufen rezeptfrei eyes, from the outer eyelids. Clomiphene is the most commonly used medication in india.
The human proteome accounts for more than 30,000 proteins that have multiple biological functions in the human body. However, more than >80% of proteins are still out of reach and remain undruggable targets. Targeted protein degradation has recently emerged as a novel pharmacological modality that promises to overcome small molecule limitations whilst retainding their key advantages.
The PROTAC technology takes advantage of the ubiquitin–proteasome system to selectively degrade a protein of interest (POI). In brief, a PROTAC is a bifunctional heterodimer that binds simultaneously to a POI and to an ubiquitin E3 ligase, the two ends being linked together by a chemical tether. The close vicinity of the POI and the E3 ligase caused by the PROTAC triggers its ubiquitination. The tagged POI is then recognized and decomposed by the proteasome 26S, therefore freeing the PROTAC for further iterative cycles of degradation. Thus, only sub-stoichiometric amounts are needed for potent activity. In comparison with a small-molecule inhibitor that requires high systemic exposure to sustain a pharmacological effect, the catalytic nature of PROTACs gives them the advantage to act effectively with a low systemic exposure, which is translated into reduced off-target problems and toxic side effects.
This report evaluates the industry landscape of targeted protein degradation with novel PROTAC and molecular glue technologies and compounds. The report is based on the identification and description of 20 major biopharmaceutical and 24 technology-focused companies with targeted protein degradation technologies and research and development activities.
The report brings you up-to-date with information about and analysis of
- Approaches of Targeted Protein Degradation with heterobifunctional PROteolysis‐TArgeting Chimeras (PROTACs) and monovalent molecular glue compounds;
- Stakeholders in the field: technology and major pharmaceutical companies and investors;
- Technologies of Targeted Protein Degradation;
- Targets and therapeutic area selected for PROTAC and molecular glue drug discovery;
- PROTAC Optimization: target identification, novel E3 ligases, ligase binders, linkers; ternary complex analysis
- New Approaches: lysosomal degradation, bio-PROTACs
- Preclinical and clinical experience with selected PROTACs and molecular glues;
- Financing situation of technology companies and key investors in the field
- Partnering deals with financial terms;
- Major pharmaceutical companies: in-house technologies, R&D, collaborations and equity purchase.
The report Targeted Protein Degradation by Novel PROTACs and Molecular Glues 2020: a landscape analysis of companies, technologies, targets, investors and partners from an industry perspective can be acquired at La Merie Publishing’s online store www.lamerie.com: https://lamerie.com/report/targeted-protein-degradation-by-novel-protacs-and-molecular-glues-2020-a-landscape-analysis-of-companies-technologies-targets-investors-and-partners-from-an-industry-perspective/
About La Merie Publishing
La Merie Publishing is an independent business information provider for the biotechnology and pharmaceutical industry. La Merie Publishing prepares brief and full reports as well as competitor analysis reports and target pipeline lists, the latter two in a tabulated format with structured listings of industry-relevant data. La Merie Publishing products can be purchased the online store www.lamerie.com and at selected Resellers.
The focus of our products is directed towards therapeutic biologics, such as antibodies, proteins, peptides, vaccines and gene & cell therapy. La Merie pays special attention to biosimilar antibodies and proteins, antibody drug conjugates, bispecific antibodies, TCR & CAR engineered antibodies, mRNA vaccines & therapeutics, oncolytic viruses and immuno-oncology in general.
To leverage its expertise and knowledge accumulated in the in-house database, La Merie Publishing offers custom report preparation services for corporate clients, including, but not limited to, pipeline analysis reports, drug profiles and any other competitive intelligence elaboration of interest for our clients.
SOURCE: La Merie Publishing