La Merie Publishing released on March 07, 2023 the 17th edition of the report series about sales of Blockbuster Biologics. This report provides a compilation of the sales data of originator recombinant therapeutic proteins and antibodies in the calendar year 2022. Sales data were obtained from company publications and refer to branded products. All sales data were converted from their original, reported currency into US$ using official currency exchange rates as of February 01, 2021. Sales figures represent the sum of revenues in all territories where the products are marketed. Growth rates mostly are presented as reported (in some cases as constant exchange rates).
Publicly available 2022 sales data of biosimilar antibodies and proteins are included in the report provided from the companies. This report also includes sales data of new biologic modalities such as gene and cell therapy and RNA (antisense, siRNA).
Due to biosimilar erosion of sales of established therapeutic proteins such as erythropoietins, interferon, G-CSF, human growth hormone and FSH, these products are summarized in a new group of established therapeutic proteins.
Sales and growth rates of cancer antibodies were analyzed by subgroup, especially for the strongly growing class of PD-1 & PD-L1 antibodies.
Development of sales of the growing drug modality of antibody-drug conjugates are also presented.
A total of 71 biologic therapeutics reached blockbuster status with 2022 sales exceeding US$ 1 bln. For the first time, sales of 22 new antibody and protein products for the year 2022 were included. Antibody sales represented more than 80% of total biologics sales in 2022. In addition, commercial information about sales of selected biosimilars of recombinant antibodies and proteins is provided.
Sales data are presented for each product within the respective class of biologics. The data were analyzed to establish a ranking list of blockbuster biologics with 2022 sales higher than US$ 1 bln. Another ranking list was prepared for the TOP 30 companies according to biologics sales in 2022.
Newly included innovator biologics for which sales are reported for the first time are