Interleukin-33/Receptor Targeted Antibodies

Interleukin-33/Receptor Targeted Antibodies – Target Pipeline List

Target: Interleukin-33; IL-33; Suppression of Tumorigenicity 2 (ST2) receptor; interleukin-1 receptor-like 1 (IL1RL1)

This report provides an overview of antibodies targeting interleukin-33 (IL-33) or its receptor ST2 (IL1RL1) in clinical development for treatment of atopic diseases.

Interleukin-33 (IL-33) is an IL-1 family member, which exhibits both pro- and anti-inflammatory properties solely based on the type of the disease itself. Generally, IL-33 is expressed by both endothelial and epithelial cells and mediates its function based on the interaction with various receptors, mainly with the receptor Suppression of Tumorigenicity 2 (ST2) variants. IL-33 is a potent inducer for the Th2 immune response.

IL-33 initiates its signalling pathway by binding to the ST2 receptor, or also known as IL-1R4, with variants which are comprised of ST2L, sST2, ST2V, and ST2LV. Apart from ST2, the interaction of IL-33 with a single immunoglobulin IL-1R-related molecule (SIGIRR) has been documented as well. With exception from other IL-1 family members, IL-33 is primarily involved in the Th2 immune response induction.

Multiple studies have indicated IL-33 as a central mediator of atopic diseases, including atopic dermatitis, food allergies and asthma. IL-33 directly mediates release of disease-associated downstream cytokines, which recruit pro-inflammatory cells that mediate atopic disease.

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