Pipeline of B7-H4-Targeted Immunotherapies

This competitive intelligence report about B7-H4-Targeted Immunotherapies provides a competitor evaluation in the field of product candidates in research and development targeting B7-H4. This report will be prepared on demand within one working day upon order placement. The report lists B7-H4-targeted R&D programs by R&D phase in a tabular format and describes in brief the profile of B7-H4-targeted immunotherapies by drug modality. The report will be provided in pdf format and sent by e-mail to the customer.

As an example of this category of on demand reports, please see our free sample report of “Pipeline of 5T4-Targeted Immunotherapies”.

The B7-H4 surface antigen is overexpressed in ovarian and endometrial cancers and is often associated with poor prognosis. B7-H4 is a member of the B7 family of immune checkpoint ligands and has been shown to negatively regulate T-cell function. B7-H4 binds to an unknown receptor on T cells and inhibits T-cell proliferation and cytokine production. B7-H4 expression is elevated across a broad range of solid tumors, including ovarian cancer, breast cancer, endometrial carcinoma, cholangiocarcinoma and gallbladder carcinoma, and squamous non-small cell lung cancer tumors. B7-H4 expression is limited in normal tissue, specifically immune cells, making it an ideal molecular target.

A number or antibody modality technologies were used to generate anti-B7-H4 drug candidates undergoing preclinical and clinical development, including antibody-drug conjugates, conditionally activated antibodies, T-cell engaging bispecific antibodies and other effector-enhanced antibody molecules.