Cadherin 17-Targeted Novel Drug Modalities: a Target and Pipeline Review

BARCELONA, Spain I May 20, 2022 I La Merie Publishing released today its newest report entitled “Cadherin 17: A target opportunity to develop effector-enhanced drug modalities”. This report describes and analyzes cadherin 17 as a target opportunity for development of effector-enhanced drug modalities as of May 2022. Cadherins are a...

Targeted Protein Degradation (TPD) by proteasomal PROTACs & molecular glues, lysosomal LYTACs and autophagic AUTOTACs or ATTECs provides plenty of opportunities to drug undruggable targets

BARCELONA, Spain I March 07, 2022 I La Merie Publishing released today its newest report entitled “Targeted Protein Degradation by Proteasomal, Lysosomal & Autophagy Pathways 2022: an industry landscape analysis of stakeholders, technologies, pipeline, partnering and financing”. This report describes and analyzes the field of Targeted Protein Degradation (TPD) from...

Prodrug antibodies and cytokines generated by masking technologies provide plenty of opportunities for founders, investors and partnerships

BARCELONA, Spain I October 06, 2021 I La Merie Publishing announced the release of its newest report about antibody and cytokine prodrugs . The report “Masked Antibodies & Cytokines As Prodrugs: a landscape analysis of stakeholders, technologies, pipelines, business and financing from an industry perspective” provides a landscape description and...

How many PD-1 and PD-L1 checkpoint inhibitors do we need?

STUTTGART, Germany I June 19, 2018 I La Merie Publishing released the results of an independent search for and evaluation of PD-1 and PD-L1 immune checkpoint inhibitors in preclinical and clinical development by pharmaceutical companies. This Competitive Intelligence report analyzes the competitive field of PD-1 and PD-L1 Immune Checkpoint Inhibitors...

Druggability of intracellular targets: a challenging, but highly rewarded goal for emerging technologies to generate TCR fusion proteins, TCRL antibodies and cell-permeating biologics

STUTTGART, Germany I January 25, 2018 I A tissue-based map of the human proteome suggests that about 75 % are intracellular or secreted targets not accessible for conventional monoclonal antibody and chimeric antigen receptor (CAR) T-cell therapy (Uhlen et al., Science, 2015). Thus, the large pool of intracellular protein targets,...