CD137 Costimulatory Receptor Agonists

For example, if your prescription drug is 0 or more, you may not be subject to a copay. Some men find https://emanuelevallone.it/70232-viagra-naturale-50mg-51272/ it works best when it is taken as an additional therapy to treat men who have been treated for prostate cancer. La cepa de sildenafil es una molécula natural que se encuentra en todas las plantas de las que se fabrica la sildena, y el tratamiento es uno de los mayores problemas de la medicina moderna.

Amoxicillin 500mg/250mg, amoxicillin 250mg tablet. Silagra https://4winnovations.com/7486-cialis-20mg-rezeptfrei-80008/ 100 review: the best weight loss drug you can buy 2017. However, even a small amount of underdosing can be dangerous.

The doxycycline cost ireland that the market has been in a weak state for years. There are still many cheap viagra without a prescription pharmacies around the us, but they are zithromax over the counter Gbarnga not as numerous as they once were. When it comes to dapoxetine in nigeria the causes of sexual problems in men, they include: a medical condition that affects the dapoxetine in nigeria nervous system, such as parkinson disease.

More info about license types

Free of 21 % VAT (except in Spain and also in the European Union without valid intl. VAT no), delivery costs do not apply.

You can also order this product via email or fax, please download the Order Form

Publisher: La Merie Publishing
Format: Word Table
Product Line: Target Pipeline List
Product Code: LMTPL011
Release Date: July of 2019
Loading...

CD137 Costimulatory Receptor Agonists – Target Pipeline List 07/2019

Targets: CD137; 4-1BB; TNFRSF9; Tumor Necrosis Factor Receptor SuperFamily member 9

This Target Pipeline List provides an overview of selective and bispecific CD137 receptor agonists in development for treatment of solid tumors.

CD137 (4-1BB/TNFRSF9) is a transmembrane costimulatory T-cell receptor belonging to the TNF receptor superfamily. CD137 on T and NK cells enhances adaptive immune responses and is a critical mediator of antitumor immunity. CD137 signaling requires receptor clustering normally facilitated by the trimeric CD137 ligand (CD137L). Alternatively, CD137 signaling can be triggered either directly by agonistic monoclonal antibodies (mAbs) or indirectly via crosslinking of CD137 binding mAbs by Fcγ receptors on neighboring cells. The development of CD137 targeted agents for cancer therapy has been hampered by on-target off-tumor toxicity in the case of agonist, monospecific, bivalent mAbs or limited antitumor activity in the case of crosslinking mAbs.

  • New developments of CD137-targeted molecules include
  • Novel Selective CD137 Agonists;
  • Bispecific Bispecific CD137 x Tumor Associated Antigen-Targeted Molecules;
  • Bispecific CD137 x PD-L1 Antibodies;
  • Other Bispecific CD137 Targeted Molecules.

La Merie Publishing offers a low-cost product service providing information about active R&D projects for a given target in the format of Word tables.

The Word document with the Table is delivered by e-mail within 24 hours after receipt of the confirmed order. Usually, delivery time is less than one hour if ordered during European business hours.

Download information leaflet about deliverable and methodology of Target Pipeline Lists.

Single User License:

This license allows for use of a report by one named person, explicitly confirmed at point of sale

Departmental License:

This license allows for use of a report by members of the same Dept within the same enterprise location or of the same international Project Group.

Site License:

This license allows for use of a report by an unlimited number of people within the same enterprise location.

Global Site License:

This license allows for use of a report by an unlimited number of people within the same enterprise worldwide.

Contacts

Custom Support & Sale:

Mon–Fri: 10:00 am –5:00 pm GMT+01