CD38-Targeted Antibody & Cell Therapy – Target Pipeline List 06/2019
Targets: CD38; Cluster of Differentiation 38; ADP-ribosyl cyclase 1; ADPRC1
This Target Pipeline List provides an overview of CD38-targeted antibody and cell therapeutics in development for treatment of multiple myeloma.
Multiple Myeloma is a hematological cancer characterized by proliferation of malignant plasma cells in the bone marrow. MM represents the second most frequent hematological malignancy, accounting 1% of all cancer and 13% of hematological tumors, with ~9,000 new cases per year. Multiple myeloma (MM) cells express high levels of the transmembrane glycoprotein CD38, while CD38 is expressed at relatively low levels on normal lymphoid and myeloid cells, and in some non-hematopoietic tissues. This expression profile, together with the role of CD38 in adhesion and as ectoenzyme, resulted in the development of CD38 antibodies for the treatment of multiple myeloma (MM). At this moment several CD38 antibodies are at different phases of clinical testing, with daratumumab already approved for various indications both as monotherapy and in combination with standards of care in MM.
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